What to do if » Free Beta e Papp -A
Positive blood test beta/Papp A
The test’s positive result is due to the blood test (duotest/dualtest/bitest/ integrated test /ultrascreen)
Variations in the distribution of FreeBeta -Hcg in Trisomy 21
The value is provided with a number known as MoM.
For example a MoM of 4 is considered to be high (but not necessarily a sign that there are problems!). The absolute value defined by the laboratory (for example PAPP-A 2,930 mlU/ml) by itself doesn’t not indicate anything. It is dependent on many other variables (gestational age, weight, etc..), that only the software is able to analyze and translate into a useful data. This data is known as MoM (multiples of the median)
Variations in the distribution of Free B-HCG in Trisomy 21
Variations in the distribution of PAPP-A in Trisomy 21
Based on the values of the specimen, it is possible to have an indication on which kind of chromosomal abnormality to test for.
In cases of trisomy 21, the values tend to be disassociated. One tends to be higher than the average (B-Hcg), while the other will be lower (PAPP-A)
With trisomies 13 and 18, both values will be low
It is only when the values are outside the average, especially when the PAPP-A is low (less than 3 MoM) that a doctor should consider conducting further investigation to ensure avoiding maternal predisposition to pregnancy complications in the III trimester.
To ensure that the results obtained are reliable, expertise and the use of high quality equipments remains essential. The laboratories analyzing the serum maternal biochemistry have also to undergo a process of accreditation and continuous quality control.
The doctor performing the examination, will have to ensure that other variables (such as wrong temperature) which have the potential of altering the results have not contaminated the sample.