Duo test / Combined test » Pre-eclampsia
Preclampsia develop at first trimester and affects the mother at third trimester.
Pre-eclampsia is the development of high blood pressure and loss of protein in the urine during the second half of pregnancy.
Pre-eclampsia affects about 2% of pregnancies and in a few of such cases there is a risk to the life of both the mother and the fetus.
Identification of women at high-risk of developing pre-eclampsia could potentially improve pregnancy outcome. Intensive maternal and fetal monitoring in such patients would lead to an earlier diagnosis and treatment of the disease to avoid the development of serious complications.
The underlying mechanism for pre-eclampsia is thought to be poor development of the placenta.
The patient-specific risk of developing pre-eclampsia can be predicted by a combination of:
1. factors in the maternal history, including racial origin, weight, and history of previous pregnancy affected by pre-eclampsia
2. measurement of maternal blood pressure
3. ultrasound measurement of blood flow in the blood vessels that supply the placenta (uterine arteries)
4. measurement of placental products in maternal blood
Screening by this combined approach could identify about 90% of patients that will subsequently develop severe pre-eclampsia
Treatment of this disease should start at first trimester